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User Report: Syro I, University of Tokyo. The Suga Laboratory at RCAST, University of Tokyo, uses the Biotage Syro I automated peptide synthesizer for scaling up the chemical synthesis of non-standard peptides.
Dr. Ana Perez-Lopez is a postdoctoral fellow in the lab of Prof. Juri Rappsilber at Technische Universität Berlin. She found some time to talk to us about the world of organic synthesis.
Recently, the Thorn-Seshold Research Group at Ludwig Maximilian University of Munich (LMU) purchased a Biotage® Selekt flash purification system to help them with their work. Biotage caught up with two of the researchers, Markus Müller and Li Gao, both Ph.D. students, to hear about their experiences with the system.
In this customer case we talk to Florian Wimmer and Natalie Schunck, Ph.D. Students working in the field of chemical materials science at the Department of Chemistry in the University of Konstanz, Germany. Florian and Natalie are working with their recently purchased Biotage® Selekt system, which has proved to be important for their work.
I got to take a tour of the undergraduate lab at California State University, San Marcos with Dr. Robert Lafe. His lab is one of the first to have the new Biotage® Selekt Flash Purification System paired with the Sfär columns. We discussed how his undergraduate researchers were impacted by the broadened capabilities and their opportunity to learn about new instruments, and how it has affected his own research in his goals to gain tenure at the university.
Dr. Picado works within the Structural Genomics Consortium (SGC), housed under the Eshelman School of Pharmacy at the University of North Carolina. Their team consists of chemists and biologists who all work under the SGC. We were able to discuss Dr. Picado’s most recent project at SGC and why Biotage’s columns made such an impact.
On one of the top floors in the Baylor College of Medicine Neurological Research Institute, I visited the Center for Drug Discovery and learn from the Director and Medicinal Chemistry Leader, Dr. Justin Anglin, about muscle cachexia as well as their innovative projects focused on male contraceptives. We were able to take a tour of their state-of-the-art lab after which includes a full suite of Biotage products, something Dr. Anglin uses every day.
I met with Professor Sabra Botch-Jones in the Boston University Medical campus to talk about her career in forensic chemistry. During this interview, I learnt more about forensics than I’ve ever learned watching NCIS, and gained an insight into her fascinating career.
Interview with Dr. László Kürti and Nicole Behnke at Rice University in Texas about their recent projects, how they use the Isolera™, and interesting chemistry .
We met with Richard E. Johnsson, Ph.D., Head of Peptide Chemistry at Red Glead Discovery, Lund, Sweden, where he told us about using Biotage products in his workflow.
On a crisp December day, I travelled up to Queens, New York to speak with Dr. Aaron Muth from St. John’s University about his work in cancer research with Biotage lab equipment and specifically the SNAP Bio cartridges. As an Assistant Professor of Medicinal Chemistry, Dr. Muth and the members of his research group use our equipment every day. We chatted about his research, students, and the needs related to tools and equipment.
PeptiDream Inc. relocated their head office in August 2017 and established its new research center in the Kawasaki City International Strategic Center. The expanded facility is expected to spawn innovative new drugs. The base instrumentation is provided by Biotage. R&D Director Keichi Masuya and his staff elaborate on the development.
Dr. Simon Hammann is Postdoctoral Researcher at the Department of Anthropology and Archaeology, University of Bristol. By combining chemistry with archeological research, he is able to look back in time and has produced the first direct chemical evidence for dietary cereal processing among Romans.
On Aug 30, 2017 a scientific literature search for the keywords Biotage AND peptide was performed by Biotage personnel. The search identified 5380 peer-reviewed publications from the global community, excluding patents and simple citations. Below are approximately 100 titles illustrating the breadth and depth of research in which Biotage tools are utilized.
Ease of use is what stands out as the top feature of Isolera™ flash chromatography system for Professor Anna Bernardi, head of the synthetic organic chemistry research group at the University of Milan. Her current research goal: developing sugar-like molecules, called glycomimetics, for healthier life.
Dr. Andrew Jamieson leads a team of peptide chemists at the University of Glasgow, where they synthesize complex molecules for chemical biology applications. An important tool that contributes to their success has been Biotage® Initiator+ Alstra™ microwave peptide synthesizer, and they are even breaking the dogma that only HPLC can be used for peptide purification, by using cutting edge reversed phase flash purification techniques provided by Biotage.
Sanford Burnham Prebys Case Study. Fewer transfers and the ability to evaporate difficult solvents right in the scintillation vial has made Biotage® V-10 the go-to evaporator at Sanford Burnham Prebys (SBP), a top medical research institute.
Customer Case: Japan Frozen Foods Inspection Corporation. The Japan Frozen Foods Inspection Corporation (JFFIC) made the transition from traditional mouse testing of shellfish toxins, to instrumental analysis by developing original methods. In the sample preparation procedure JFFIC uses EVOLUTE® ABN hydrophilic/hydrophobic SPE columns from Biotage.
Customer Case: Hitachi, Ltd. Healthcare Innovation Center. Hitachi’s R&D group has developed a new method for analyzing pharmacodynamics in cultured cells, in a study aimed at improving the pass rate in clinical trials. Mr. Ryosuke Takahashi tells the story.
At Chiba University’s Graduate School of Medicine and its affiliated hospital, researchers are developing an LC-MS/MS method for vitamin D analysis using ISOLUTE® SLE+ and other Biotage products. We interviewed Professor Mamoru Satoh at the Disease Proteomics Center and Mr. Takashi Ishige from the Inspection Department at the affiliated hospital.