
Biotage® Initiator+ represents the latest in microwave synthesis performance. This instrument’s high-end specifications enable the chemist to explore new areas and perform the latest of innovations in chemistry. A reliable and upgradeable platform that allows chemists to make great discoveries in less time.
Temperature range | 40–300°C |
Temperature increase | Typically 2-5 °C/sec depending on solvent and power applied |
Reaction time | Up to 96 hours. Typically, most reactions require 2 to 15 minu |
Pressure range | 0–30 bar (3 MPa; 435 psi) |
Power range | 0–400 W from magnetron at 2.45 GHz |
Reaction volumes | 0.2–20 mL |
Agitation | Variable magnetic stirrer (300-900 RPM) |
Sample processor | Upgradable with Robot Eight / Robot Sixty Processing capacity |
Temperature | Operating Temperature: 18–32°C Storage and transportation temp |
Humidity | 20–95% at room temperature |
Electrical supply | Europe: 220–240 V~, 50 Hz (5 A) US and Japan: 100–120 V~, 50/6 |
Maximum power consumed | 1100 VA |
Cooling | Pressurized air supply: > 60 l/min (2.1 cubic feet/min), 2.5 to |
Weight | Initiator+: 21 kg (48.5 lbs) |
Dimensions (WxDxH) | Initiator+: 365 x 422 x 421 mm (14.4"x 16.6" x 16.6") |
Max sound level | 70 dB(A) |
Touch screen | 10.4" |
Ethernet LAN | Complies with IEEE 802.3 (ANSI 8802-3) |
USB | USB 2.0 |
Achiving/back-up | Via USB |
Printing | Via LAN |
Upgrade path | Robot Eight and Robot Sixty (see automation solutions) |
Certifications | CE, CSA certified |
The cyclic peptide mupain-1 (CPAYSRYLDC) is an inhibitor of the cancer-related urokinase-type plasminogen activator. Here we show the synthesis of a non-natural arginine building block precursor using MAOS.
Tags: Application Notes
PNA oligomers have interesting properties such as their increased thermal and chemical stability and resistance to enzymatic degradation which drives their use in various molecular biology, molecular diagnostic, microarray, biosensor and antisense applications. In this study we synthesize two PNA oligomers on a small scale using the Biotage® Initiator+ Alstra™ microwave peptide synthesizer.
Tags: Application Notes
This application note describes a method for sample preparation
of different matrixes prior to amino acid analysis according to IS
ISO 13903:2005 or the similar AOAC Official Method 994.12 using
Biotage® Initiator+ to speed up the process.
Tags: Application Notes
The formation of diarylamines by reacting anilines with aromatic electrophiles is, usually, a reaction demanding long reaction
times, high temperatures and strong bases, in order to obtain acceptable yield, due to the low nucleophilicity of anilines.1 The Buchwald-Hartwig cross-coupling reaction is a very useable and elegant solution to this problem.2,3,4 Anticipating the classical metal-free SNAr-amination reaction, without using Pd-catalysts and strong bases, with only higher temperature and pressure as tool as depicted in the Scheme below,1 gives no product at all at 180 ºC and very low conversion (9 %) at 220 ºC for 15 minutes when heating by microwaves.5 Remainder was unreacted starting material.
Tags: Application Notes,
English
The formation of diarylethers by reacting an arylhalide and phenol is usually a reaction demanding long reaction times, high temperatures and strong bases, in order to obtain acceptable yield. The substitution patent of the electrophile and the nucleophile affects the reaction times mostly. A sterically hindered electrophile and a strongly deactivated nucleophile as outlined in the (Scheme 1) below, gives a very low yield (13 %) at conventional reflux for 2 weeks.1,2 Remainder was
recovered starting material. We have previously reported the dramatically shortened reaction time to 1 hour along with improved yield running the reaction outlined in the Scheme by heating by microwaves.
Tags: Application Notes,
English
Quinolines are an important class of broad-spectrum antibiotics1 that were traditionally obtained by refluxing an aniline and diethyl ethoxymethylemalonate (Scheme 1) for several hours often in low yield.2 Heating the reaction mixture by microwaves to temperatures above the boiling points, with or without solvents, improves the yields and shortens the reaction time dramatically.3-6
Tags: Application Notes,
English
A one-pot process for the preparation of Acyclovir from guanine is described. The key step involves a trimethylsilyl triflate (TfOTMS)-catalysed reaction of silylated guanine with 1,3-dioxalane under microwave irradiation. With this method, the yield is in the same range as with conventional heating, but the speed of the reaction is increased by a factor of 85.
Tags: Application Notes
Heck reactions utilizing a thermostable catalyst in combination with microwave irradiation have been performed. A substantial enhancement of reaction rates as well as excellent regiocontrol could be obtained under microwave conditions without using inert gas. A slight increase in yield was also noted.
Tags: Application Notes
Solid-Phase Suzuki couplings using microwave irradiation have been performed. The reaction times were considerably shorter
than those required using conventional heating conditions.
Tags: Application Notes
An efficient 2-step synthesis of bezafibrate from tryamine under microwave conditions has been developed using SmithReactionKitTM and Microwave Syntheses technology.
Tags: Application Notes
The rapid synthesis of the non-steroidal anti-inflammatory agent Fenclofenac (2-(2,4-dichlorophenoxy)phenyl acetic acid) under microwave irradiation is reported. Modified reaction conditions of traditional Ullmann ether coupling resulted in high yields of the diaryl ether. The Willgerodt–Kindler transformation and subsequent hydrolysis of thioamide resulted in 52%
overall yield of Fenclofenac.
Tags: Application Notes
Biotage has developed tools for every
step of the organic process, with the entire workflow in mind.
This dedicated suite of products vastly expands the
range of options in order to truly accelerate discoveries
of new molecules for future innovations.
Tags: Brochures
Speeding up reactions has never been easier. Biotage microwave
synthesizers are the first-choice tools for organic chemists who
need to accelerate their production of new compounds.
Initiator, Initiator+, robot, vials, phase separator, work up tools
Tags: Brochures
On Aug 30, 2017 a scientific literature search for the keywords Biotage AND peptide
was performed by Biotage personnel. The search identified 5380 peer-reviewed
publications from the global community, excluding patents and simple citations.
Below are approximately 100 titles illustrating the breadth and depth of research in
which Biotage tools are utilized.
Tags: Customer Cases
User Case: Kissei Pharmaceutical Co., Ltd. One of Japan’s innovative pharmaceutical companies uses Isolera™ flash
purification systems and Biotage® Initiator+ microwave synthesizers in the
development of new prescription drugs. Modern lab instruments contribute to
efficient use of time and resources at Kissei Pharmaceuticals.
Tags: Customer Cases
User report: Initiator. Prof. Nakamura at the Gakushuin University has described the Initiator as an essential tool for his group’s cutting-edge research. We asked Prof. Nakamura for his views on the latest trends in the fields of organic synthesis and drug discovery.
Tags: Customer Cases
Translated versions of the Safety chapter available in the Biotage® Initiator+ Installation and Safety document (P/N 355976). Languages: Danish, Dutch, Finnish, French, German, Italian, Japanese, Spanish, and Swedish.
Tags: Danish,
Dutch,
Finnish,
French,
German,
Italian,
Japanese,
Manuals & User Guides,
Spanish,
Swedish
Biotage® Initiator Installation and Safety
Tags: English,
Manuals & User Guides
Quick Start, Instrument Overview, Software Overview, Biotage® PathFinder, Getting Started with Microwave Synthesis, Open Reactor Access, Maintenance, and General Information.
Tags: English,
Manuals & User Guides
Initiate success in Chemical education with Microwave Assisted Organic Synthesis. This leaflet contain example reactions that could be adapted for use in the teaching laboratory.
Keywords: initiator+
Tags: English,
Manuals & User Guides,
Pharma
Vial preparation:
1) Remember to add stir bar for efficient mixing. Catalysts, salts, or visible precipitate should be washed clear of head space and into solution. Particles adhering to glass head space could cause excessive heating increasing possibility of failure of vial. Stay within specified vial volume range (see diagram for proper filling).
Tags: Manuals & User Guides
Presentation outlining MW synthesis: conditions, vial venting.
Tags: Manuals & User Guides
Project I
•Metal-mediated [2 + 3] cycloaddition to coordinated nitriles
-- synthesis of new transition metal complexes
-- synthesis of new heterocycles
-- enantioselective synthesis of heterocycles
role of microwaves?
Project II
• Platinum-catalysed cycloisomerisation of alkynes
-- Synthesis of Taxol-like compounds
-- highly efficient and atom economic chemistry
role of microwaves?
Tags: Manuals & User Guides
We have successfully developed a rapid and efficient microwave-assisted protocol for the preparation of Neu5Ac congeners that are important intermediates for clinically-relevant derivatives of Neu5Ac. The syntheses were performed using readily available reagents, improved on established techniques, and used more benign reagent for peracetylation. Moreover, the protocol that we developed is 1 to 2 orders of magnitude faster than conventional methods.
Initiator+ SPWave synthesis system
Dhananjaya Sahoo, I. Abrrey Monreal, and Jonel P. Saludes
Tags: English,
Posters
In order to obtain a fast synthesis of an N-unprotected tripeptide, microwave (mw) assisted deprotection, coupling and partial deprotection were applied starting with a purified protected dipeptide [Fig. 1]. The three consecutive mw assisted steps were performed without any intermediate purifications and were accomplished within some 30 minutes. The resulting crude mixture containing the Boc deprotected tripeptide ester was shown to be quite complex [Fig. 2]. The crude product was subjected to automated reversed phase flash chromatography, followed by automated fraction pooling and “thin film evaporation”. The total time for the entire procedure was 1 h 20 min. The purity of the product was > 99%.
Tags: Posters
For high efficiencyin parallel synthesisand method developement short reaction timesare essential. We have examinedthe possibilityof maintaining reported selectivities[1]in rapid, high temperaturepalladium-catalyzed asymmetric allylic alkylations. Reactions were promotedby useof singlemode microwave heating(vide infra),[2]which oppositeto conventional oilbath heating(wallheat transfer) rapidlyand almost homogeneouslyheat largeparts of the sample(internalheat transfer).
Tags: Posters
The Initiator+ is a flexible system that utilizes all Biotage vials, from 0.2 to 20 mL,
in any order or combination, at any time without system modifications, delivering greater flexibility and direct scale-up from milligrams to grams.
Tags: Product Notes
The 60-position sample bed supports the production of focused libraries, multi-user environments and scale-out. Flexible operation enables the use of both large and small vials in combination at any time and in any order without manual intervention.
Tags: Product Notes
Join our seminar on organic chemistry workflow on February 22nd in Rome, Italy. Biotage workflow solutions for organic chemistry can reduce the time taken to synthesise molecules by a fact...
25 October 2017Models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent. Today, chemists multitask to be more efficient, but this does not reduce the actual time t...
27 September 2017A quick literature review recently identified 5380 peer-reviewed publications from the global community on peptide synthesis where Biotage equipment has been used. The body of published literature ...
17 December 2015Mr. Shigeru Yonekubo at Kissei Pharmaceutical Co., Ltd. is right at the center of advanced drug development. In this interview, he explains how his company benefits from flash purification sys...
17 July 2015Biotage® Initiator+ is top contender in a review paper on the current market offerings in microwave assisted organic synthesis (MAOS) and its applications. The huge number of microwave...
02 July 2015Researchers use Biotage synthesis and purification products for their investigation into kinase inhibitors as targets for anti-cancer therapy. The research group specializes in Polo-like k...
24 June 2015Process up to 60 microwave reactions unattended on a Biotage® Initiator+ microwave synthesizer equipped with the Robot Sixty option. Automated microwave synthesis is ideal for method d...
11 June 2015Learn how to control the advanced parameters on the Biotage® Initiator+ microwave organic synthesizer. Biotage® Initiator+ gives you full control over every step of your reac...
26 May 2015How easy does microwave assisted organic synthesis get? Find out in this Biotage® Initiator+ video. Microwave heating is by far the superior choice for synthesizing novel compounds, an...
20 May 2015A research group from Kyoto University have recently published a method for the chemical synthesis of La1, a 73 amino acid cysteine-rich peptide from scorpion venom. La1 is a 73-residue pe...
29 April 2015Biotage® Initiator microwave synthesizer was used in a study on synthesis of tebufenpyrad analogues to explore potential druglike properties. A number of fluorinated and fluorine-free ...
04 February 2015Biotage will attend the 22nd SCT Young Researchers in Paris, France 4-6 February 2015 Read More http://www2.sct-asso.fr/form.php?langue=english&cle_menus=1187970162
23 September 2014Biotage is attending MipTec 2014, Europe’s leading event for Drug Discovery and Life Sciences Research. “Translating Science into Drugs” 23-25 September 2014Basel, Switzerl...
Durable and safe reactions at all times. Our high precision microwave vials are designed and tested to withstand pressures beyond 30 bar in a wide range of conditions.
NOTE: Biotage® Microwave Reaction Vials (in combination with the caps and septa) are ONLY to be used in Biotage Microwave Synthesizers.
This product was withdrawn on April 1st 2017. The service is available for current subscribers, but no longer offered to new subscribers.
Biotage® Initiator+ can be upgraded from a single-sample manual format to an automated 8- or 60-position system. The modular design allows a user to add on different automated sample processors dependent on throughput requirements.
Part No. | Description | Product type | Pack Size | Price | ||
![]() |
356000 | Biotage® Initiator+ Robot Eight - Microwave System EU | Instruments | 1 | Log in for price | |
![]() |
356001 | Biotage® Initiator+ Robot Eight - Microwave System US/JPN | Instruments | 1 | Log in for price | |
![]() |
356003 | Biotage® Initiator+ Robot Sixty - Microwave System EU | Instruments | 1 | Log in for price | |
![]() |
356004 | Biotage® Initiator+ Robot Sixty - Microwave System US/JPN | Instruments | 1 | Log in for price | |
![]() |
356006 | Biotage® Initiator+ Microwave System EU | Instruments | 1 | Log in for price | |
![]() |
356007 | Biotage® Initiator+ Microwave System US/JPN | Instruments | 1 | Log in for price |
Part No. | Description | Product type | Pack Size | Price | ||
355366 | Initiator Waste Tray Inserts | Accessories | 5 | Log in for price |
Part No. | Description | Product type | Pack Size | Price | ||
354974 | Initiator Cavity Air Guide | Spare parts | 1 | Log in for price |
Press the large touch-screen and heat your organic reagents to 300 °C in just a few seconds. Biotage® Initiator+ does just that, and adds intelligent features that make innovation fast, reliable and safe.
Biotage® Initiator+ represents a new generation of synthesizer instruments for organic, medicinal, materials, nano and polymer chemistry professionals. It is an upgradeable and reliable platform allowing chemists to make great discoveries in less time.
Higher temperatures and pressures of up to 300 °C and 30 bar open new possibilities to perform difficult reactions. This allows for more flexibility in choosing a solvent. Even low boiling point solvents can now be run at higher temperatures. Using “Regulate on pressure” enables the reaction to reach highest possible temperature during the run. With the addition of the optional fiber optic probe, it is possible to measure the reaction temperature inside the vial for a higher degree of control.
Load and run your samples using a touch screen for simple and intuitive navigation without the need for an external computer, keyboard or mouse. Results can be emailed directly to the user after a run, or downloaded through the USB port at the front of the instrument.
Use four different vial sizes in any order or combination at any time, without system modifications, for greater flexibility and direct scale-up of milligrams to grams.
Upgrade from a Biotage® Initiator+ by connecting the Biotage® SP Wave peptide synthesis module and the Robot Eight kit to perform microwave assisted peptide synthesis with vortex mixing to ensure homogeneous heat distribution.
The large touch screen display provides an easy-to-use experience from set-up to results. By using the Biotage Wizard, the user is guided through the set-up of experiments step-by-step. It also includes assistance in converting conventional conditions to microwave synthesis parameters.
The reaction vessel is secured with a triple-tier safety lock to ensure maximum operator safety at all times. This in combination with high grade aluminum and a safe explosion box ensures maximum operator safety, even at high temperature and pressure.
Biotage’s world-class field service organization serves customers on site to provide the highest quality personalized support.