Biotage® Initiator Classic

Discontinued

This product was withdrawn on April 1st 2014.

Temperature	40-250 °C (104-482 °F)
Temperature increase	2-5 °C/sec (3.6-9 °F/sec)
Pressure range	0-20 bar (2 MPa, 290 PSI)
Power range	0-400 W at 2.45 GHz
Reaction vials	4 sizes: 0.2-0.5, 0.5-2, 2-5, 10-20 mL
Vial volume range	0.2-20 mL (EXP) 0.5-5 mL
Agitation	Variable magnetic stirrer (300-900 RPM)
Sample Processor	upgradeable with Robot Eight/ Robot Sixty
Processing capacity	8 vials / 60 vials
Rack capacity (large)	2x2 vials / 2x12 vials
Rack capacity (small)	2x4 vials / 2x30 vials
Temperature	18-32 °C (65-90°F)
Humidity	20-95% RH
Electrical supply	EU: 220-240 V, 50 Hz (5 A) US: 120 V, 60 Hz (10 A) JP: 100V, 5
Maximum power consumed	1000 VA
Standby/Off	45/0W
Pressurized air supply (reaction cooling) Cooling	Pressurized air supply >60 L/min (2.1 cubic feet/min), 2.5 – 4 b
Weight Dimensions	48.9 lb (22.2 kg) 14.4” x 15.9” x 16.3” W x D x H (365mm x 405mm
Touch screen	6.4”
Ethernet LAN	Complies with IEEE 802.3 (ANSI 8802.3) MII
Archiving/Backup & Printing	Via the LAN, Biotage HUB, USB memory stick, or direct connection
Upgrade Path	The Initiator system can be upgraded to an 8 or 60-position sys
Certifications	CE, CSA certified

The trend pharma industry is clearly to speed up the process from lead identification to selection of candidate drug. One of the major limitations is the availability of larger amounts typically hundreds of grams, of the potentially active substance to be further investigated
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Part No: P020 Published: 2008 0.16 MB Format: pdf Download

Reduction of Aldehydes and Ketones Using Solid Supported Borohydride and Microwave Heating

One very common transformation in organic synthesis is the reduction of aldehydes or ketones to the corresponding primary or secondary alcohols (Scheme 1) using sodium borohydride as hydride donator. This reaction generally generates the product in very high yield. Among the draw-backs are long reaction times, that a large excess of reagent is needed and that the reaction mixture must be extracted in order to separate the inorganic salts from the product.
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Part No: P014 Published: 2006 0.13 MB Format: pdf Download

Microwave Assisted 2,5-Diketopiperazine Formation from Protected Dipeptides

The formation of 2,5-diketopiperazines from a water suspension of N-Boc protected dipeptide alkyl esters or dipeptide alkyl esters was induced by microwave assisted heating (Scheme 1). The products, which precipitated, were obtained in good yields. However, epimerisation/diastereomer formation was found to various extents depending on the amino acid sequence and the applied reaction temperature.
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Part No: P006 0.09 MB Format: pdf Download

» PRODUCT NOTES

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Biotage® Initiator is the predecessor to the Initiator+, and is an affordable entry-level instrument for standard routine synthesis operations. Providing the same level of reliability and safety as the Initiator+, it delivers basic functions for organic microwave synthesis.

Fully integrated computer

Load and run your samples using a touch screen for simple and intuitive navigation without the need for an external computer, keyboard or mouse. Results can be emailed directly to the user after a run, or downloaded through the USB port at the front of the instrument.

0.2 to 20 mL without system modifications

Use four different vial sizes in any order or combination at any time, without system modifications, for greater flexibility and direct scale-up of milligrams to grams.

Modular design

The Initiator is already prepared for a Robot Eight or Robot Sixty due to its modularity. The system can easily be upgraded from a single-sample manual format to an automated 8- or 60- position system.

Enhanced Heating Performance

The single-mode applicator and the Dynamic Field Tuning™ features offer faster and more powerful (400 W) heating of a broader range of solvents.

Best-in-class safety

All Biotage microwave synthesizers are designed for safe operation at elevated temperatures and pressures. The Initiator triple-tier safety lock feature ensures maximum operator safety at all times.

Biotage 1-Point Support™

Biotage’s world-class field service organization serves customers on site to provide the highest quality personalized support.

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Biotage® Initiator Classic

Discontinued

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