- Organic Synthesis
- Biotage® Robot Eight & Robot Sixty
Sample Preparation
Horizon Food & Environmental Products
Organic Synthesis
Peptide Chemistry
Flash Purification
Work-up Products
Evaporation & Concentration
Process Development
Industrial Products
Service & Support
- Automated Sample Preparation Instruments
- Manual Sample Preparation & Accessories
- ISOLUTE® FILTER+ High Performance Filtration Plates
- ISOLUTE® PPT+ Protein Precipitation Plates
- ISOLUTE® PLD+ Protein and Phospholipid Removal Products
- ISOLUTE® HYDRO DME+ Dual Mode Extraction Products
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- ISOLUTE® SPE Columns and Plates
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- ISOLUTE® 101
- ISOLUTE® AL-A, AL-N & AL-B
- ISOLUTE® Accessories
- ISOLUTE® C18
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- ISOLUTE® C2
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- EVOLUTE® SPE Columns and Plates
- AFFINILUTE™ MIP Columns
- Service Agreements - Europe
- Service Agreements - North and Latin America
- Discontinued Products
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- Biotage® Syro Wave™
- Biotage® Advancer
- Biotage® Atlantis
- Biotage® ELSD-1080
- Biotage® Initiator Classic
- Biotage® Resolux™
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- EVOLUTE® ABN
- EVOLUTE® AX
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- FlashMaster Personal Plus
- KILOPREP Systems and Consumables
- SAM
- SAP
- TurboVap® Classic 500
- TurboVap® Classic II
- TurboVap® Classic LV
Biotage® Robot Eight & Robot Sixty
Automation for Microwave Assisted Organic Synthesis
Biotage® Initiator+ can be upgraded from a single-sample manual format to an automated 8- or 60-position system. The modular design allows a user to add on different automated sample processors dependent on throughput requirements.
| Sample processor | Robot Eight/Robot Sixty |
| Processing capacity | 8 vials/60 vials |
| Rack capacity (large) | 2x2 vials/2x12 vials |
| Rack capacity (small) | 2x4 vials/2x30 vials |
| Vial sizes | 0.2–0.5; 0.5–2; 2–5; 10–20 mL |
| Operating temperature | 18–32 °C |
| Storage temperature | -25 °C to 60 °C |
| Humidity | 20–95% at room temperature |
| Electrical supply | Supplied by Initiator |
| Certifications | CE, CSA certified |
| Initiator+ Eight | 28 kg (61.7 lbs) |
| Initiator+ Sixty | 34 kg (75 lbs) |
| Initiator+ Eight | 400 x 500 x 580 mm (15.7" x 19.7" x 22.8") |
| Initiator+ Sixty | 625 x 422 x 470 mm (24.6" x 16.6" x 18.5") |
| Initiator Sixty | 625 x 405 x 470 mm (24.6" x 15.9" x 18.5") |
» APPLICATION NOTES
Microwave assisted organic and peptide synthesis of a non-natural arginine residue and incorporation into a cyclic peptide mupain-1 analogue
The cyclic peptide mupain-1 (CPAYSRYLDC) is an inhibitor of the cancer-related urokinase-type plasminogen activator. Here we show the synthesis of a non-natural arginine building block precursor using MAOS.
Tags: Application Notes
Nucleophilic Aromatic Substitution (SN Ar)-Amination A Comparison of Heating using Microwave Irradiation to 250 oC and 300 oC
The formation of diarylamines by reacting anilines with aromatic electrophiles is, usually, a reaction demanding long reaction
times, high temperatures and strong bases, in order to obtain acceptable yield, due to the low nucleophilicity of anilines.1 The Buchwald-Hartwig cross-coupling reaction is a very useable and elegant solution to this problem.2,3,4 Anticipating the classical metal-free SNAr-amination reaction, without using Pd-catalysts and strong bases, with only higher temperature and pressure as tool as depicted in the Scheme below,1 gives no product at all at 180 ºC and very low conversion (9 %) at 220 ºC for 15 minutes when heating by microwaves.5 Remainder was unreacted starting material.
Tags: Application Notes,
English
» BROCHURES
Organic Chemistry - Products from Start to Finish
Biotage has developed tools for every
step of the organic process, with the entire workflow in mind.
This dedicated suite of products vastly expands the
range of options in order to truly accelerate discoveries
of new molecules for future innovations.
Tags: Brochures
Microwave Synthesis - Fourth Generation Systems
Speeding up reactions has never been easier. Biotage microwave
synthesizers are the first-choice tools for organic chemists who
need to accelerate their production of new compounds.
Initiator, Initiator+, robot, vials, phase separator, work up tools
Tags: Brochures
» MANUALS & USER GUIDES
Tips and Tricks - Microwave Synthesis
Presentation outlining MW synthesis: conditions, vial venting.
Tags: Manuals & User Guides
Use of Microwave in Synthesis of Organic and Inorganic Compounds of Potential Medical Application
Project I
•Metal-mediated [2 + 3] cycloaddition to coordinated nitriles
-- synthesis of new transition metal complexes
-- synthesis of new heterocycles
-- enantioselective synthesis of heterocycles
role of microwaves?
Project II
• Platinum-catalysed cycloisomerisation of alkynes
-- Synthesis of Taxol-like compounds
-- highly efficient and atom economic chemistry
role of microwaves?
Tags: Manuals & User Guides
» POSTERS
Time-Efficient Chemistry: Rapid Routes from Synthesis to Isolated Compound (II)
In order to obtain a fast synthesis of an N-unprotected tripeptide, microwave (mw) assisted deprotection, coupling and partial deprotection were applied starting with a purified protected dipeptide [Fig. 1]. The three consecutive mw assisted steps were performed without any intermediate purifications and were accomplished within some 30 minutes. The resulting crude mixture containing the Boc deprotected tripeptide ester was shown to be quite complex [Fig. 2]. The crude product was subjected to automated reversed phase flash chromatography, followed by automated fraction pooling and “thin film evaporation”. The total time for the entire procedure was 1 h 20 min. The purity of the product was > 99%.
Tags: Posters
Rapid and Selective Palladium-Catalyzed Asymmetric Allylic Alkylations under Microwave Conditions
For high efficiencyin parallel synthesisand method developement short reaction timesare essential. We have examinedthe possibilityof maintaining reported selectivities[1]in rapid, high temperaturepalladium-catalyzed asymmetric allylic alkylations. Reactions were promotedby useof singlemode microwave heating(vide infra),[2]which oppositeto conventional oilbath heating(wallheat transfer) rapidlyand almost homogeneouslyheat largeparts of the sample(internalheat transfer).
Tags: Posters
» PRODUCT NOTES
Microwave Synthesis Automation
The 60-position sample bed supports the production of focused libraries, multi-user environments and scale-out. Flexible operation enables the use of both large and small vials in combination at any time and in any order without manual intervention.
Tags: Product Notes
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INSTRUCTION VIDEOS
Automated Microwave Synthesis on Biotage® Initiator+
News
25 October 2017Make Target Molecules Five Times Faster
Models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent. Today, chemists multitask to be more efficient, but this does not reduce the actual time t...
17 December 2015Efficient Lab Equipment at the Heart of Drug Development
Mr. Shigeru Yonekubo at Kissei Pharmaceutical Co., Ltd. is right at the center of advanced drug development. In this interview, he explains how his company benefits from flash purification sys...
24 June 2015Be More Efficient in the Lab By Automating Your Synthesis
Process up to 60 microwave reactions unattended on a Biotage® Initiator+ microwave synthesizer equipped with the Robot Sixty option. Automated microwave synthesis is ideal for method d...
Biotage® Initiator Classic
This product was withdrawn on April 1st 2014.
Biotage® Initiator+
Biotage® Initiator+ represents the latest in microwave synthesis performance. This instrument’s high-end specifications enable the chemist to explore new areas and perform the latest of innovations in chemistry. A reliable and upgradeable platform that allows chemists to make great discoveries in less time.
INSTRUMENTS
| Part No. | Description | Product type | Pack Size | Price | ||
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356000 | Biotage® Initiator+ Robot Eight - Microwave System EU | Instruments | 1 | Log in for price | |
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356001 | Biotage® Initiator+ Robot Eight - Microwave System US/JPN | Instruments | 1 | Log in for price | |
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356003 | Biotage® Initiator+ Robot Sixty - Microwave System EU | Instruments | 1 | Log in for price | |
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356004 | Biotage® Initiator+ Robot Sixty - Microwave System US/JPN | Instruments | 1 | Log in for price | |
ACCESSORIES
| Part No. | Description | Product type | Pack Size | Price | ||
| 353478 | Vial Rack (New) 0.2 - 5ml | Accessories | 1 | Log in for price | ||
| 354798 | Vial Rack 10-20 mL, Robot 60 | Accessories | 1 | Log in for price | ||
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355380 | Biotage® Robot Eight | Accessories | 1 | Log in for price | |
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355381 | Biotage® Robot Sixty | Accessories | 1 | Log in for price | |
| 355391 | Vial Rack, 5ml Robot 8 | Accessories | 1 | Log in for price | ||
The 8-position sample bed gives the user a compact automation solution to start scale-up process and library build-up. The 8-position system is useful in a multi-user environment or for queuing multiple reactions. Flexible operation enables the use of both large and small vials in combination at any time and in any order without manual intervention.
The 60-position sample bed supports the production of focused libraries, multi-user environments and scale-out, and use of both large and small vials in any order without manual intervention.