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Sample Delivery | 5-mL syringe pump and/or peristaltic pump |
Vial Size Compatibility | 20 mL scintillation vial |
30 mL scintillation vial | |
4 mL (3 variants) | |
Solvent Compatibility | Boiling points from 30°C to 160°C (to 205° when using an external vacuum pump) |
V-10 is not suitable for solutions containing HCl at any concentration | |
System Requirements | |
Power | 230VAC(±10%), 50Hz, 8A |
110VAC(±10%), 50/60Hz, 15A | |
Gas | Compressed Nitrogen (optional) regulated up to a maximum of 2 bar |
Dimensions (W x H x L) | 40 cm x 53 cm x 48 cm (16”x21”x18.5”) |
49 cm x 53 cm x 54 cm (19.5” x 21” x 21.5”) w. carousel | |
Weight | 45 kg (100 lb) |
50 kg (111 lb) w. carousel | |
Certifications | CE |
Interfaces Connections | RS 232 |
Accessories | |
Sample Automation | 16 position Carousel |
Liquid Handler | Gilson Liquid Handler GX271 |
Tokyo based PeptiDream Inc. is a company specializing in non-standard peptide therapeutics containing non-standard amino acids, and conducts research and development of new drug candidates. PeptiDream uses the peptide synthesizers Syro I and Biotage® Initiator+ Alstra™ for the synthesis of various kinds of peptides to support drug discovery and development.
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User Report: V-10, Sumitomo Dainippon Pharma. Sumitomo Dainippon Pharma is recognized worldwide for its highly creative drug discovery program for treating neuropsychiatric disorders, and in specialized areas with high unmet medical needs. Its Genomic Science Laboratories installed the V-10 evaporation system in 2008, which has been used extensively for drying in-house compounds. We asked two researchers at that facility, Mr. Masahiko Ikeda and Mr. Fumitaka Nishino, about their use of the V-10 in their daily work.
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Step by Step instructions how to operate V-10 Solvent Evaporation system.
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Pharma
In order to obtain a fast synthesis of an N-unprotected tripeptide, microwave (mw) assisted deprotection, coupling and partial deprotection were applied starting with a purified protected dipeptide [Fig. 1]. The three consecutive mw assisted steps were performed without any intermediate purifications and were accomplished within some 30 minutes. The resulting crude mixture containing the Boc deprotected tripeptide ester was shown to be quite complex [Fig. 2]. The crude product was subjected to automated reversed phase flash chromatography, followed by automated fraction pooling and “thin film evaporation”. The total time for the entire procedure was 1 h 20 min. The purity of the product was > 99%.
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The versatility of Biotage® V-10 enables evaporation of single samples (up to 12 mL) or large pooled volumes using V-10 pumps (syringe or peristaltic). Adding the automated vial loading/changing carousel enables unattended evaporation of up to 16 samples.
Tags: Product Notes
Tokyo based PeptiDream Inc. is a company specializing in non-standard peptide therapeutics containing non-standard amino acids, and conducts research and development of new drug candidates. PeptiDr...
21 January 2014Biotage has released a new application note for Isolera™ Dalton mass directed flash purification. Synopsis: We demonstrate the mass-directed purification of a simple peptide usin...
27 November 2013Peptide Synthesis, Purification, Mass Identification and Evaporation using the full range of Biotage instruments and consumables. Biotage® Initiator+ Alstra™ is a fully automated microwa...
05 January 2010Uppsala, Sweden, January 5, 2010 – Biotage, a leading supplier of tools and technology for medicinal and analytical chemistry, announced that a major pharmaceutical company has named the Biot...
04 January 2008[2008-01-04] Biotage to Unveil New Advanced Sample Preparation Products at PITTCON 2008 Biotage, the leading supplier of tools and technology for medical and analytical chemistry, announce...
Biotage® V-10 solvent evaporation system rapidly dries samples dissolved in both aqueous and organic solvents up to 20x faster than traditional rotary or centrifugal evaporators, leaving solvent-free product in the vial. This innovative vortex and vacuum evaporation technology was developed through collaboration with major pharmaceutical companies.
Evaporate samples up to 20x faster than traditional rotary or centrifugal evaporators using a patented combination of drying techniques, including high-speed vial rotation, uniform IR controlled heating, and vacuum drying. This unique system provides rapid evaporation of solvents with boiling points from 30 to 205 °C. Samples dried on a V-10 have little or no solvent residue to interfere with downstream analysis such as NMR.
The V-10’s high performance vacuum capability allows low temperature evaporation of high boiling solvents. Solvents include DMF, aqueous, aqueous/organic mixtures and even DMSO and NMP with the high vacuum pump option (see table 1).
Solvent |
BP (° C) |
Biotage V-10Evaporation |
CentrifugalEvaporation |
Blow-downEvaporation |
NMP | 202 | 18 minutes | N/A | N/A |
DMSO | 180 | 15 minutes | 180 minutes | N/A |
DMF | 150 | 4 minutes | 90 minutes | N/A |
Pyridine | 115 | 5.5 minutes | 70 minutes | N/A |
Water | 100 | 9 minutes | 140 minutes | 240 minutes |
Methanol | 65 | 3 minutes | 70 minutes | 40 minutes |
Cyclohexane | 81 | 2.5 minutes | 40 minutes | 20 minutes |
Table 1. Time to evaporate 8-mL of solvent at 40 ºC using Hi Boil method
The versatility of Biotage® V-10 enables evaporation of single samples (up to 12 mL) or large pooled volumes using V-10 pumps (syringe or peristaltic). Adding the automated vial loading/changing carousel enables unattended evaporation of up to 16 samples. Using the V-10 Control Center software, integrate the system with a liquid handling robot. Combine multiple fractions/samples from different test tube racks and dry them into a single vial in one operation
Bump-free vortex evaporation prevents sample loss while the system’s precise temperature control eliminates sample overheating. Maximize sample recovery with the V-10’s automatic, end-of-run detection.
Compounds are dried directly in vial of choice. Tedious tasks such as sample transfers, handling and reformatting are minimized, increasing productivity in the lab.
This environmentally friendly system captures up to 98% of solvent vapors.
The system is operated via touchpad control or the via the Control Center software. On the base unit easy-to-use touchpad control directly provides pre-programmed and user-configurable methods for optimal drying conditions. The Control Center software provides simple simultaneous control of the V10 and the integrated liquid handler.
Localized key pad operation along with built-in, solvent-resistant vacuum pump and refrigerated condenser save valuable bench space.