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ISOLUTE® SCX-2
Metal Scavenger with Affinity for Alkali Metals
ISOLUTE® SCX-2 belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also Pd, Rh, and Ru. Since SCX-2 is acidic in nature, it is typically used as a metal scavenger when the target product is not basic, to avoid the obvious acid/base product binding interactions with the scavenger.
| Shelf Life | 12 months+ |
| Capacity | 0.7 mmol/g |
| BSE/TSE Statement | yes |
| Scalable | yes |
| Particle Size | 60 microns |
| Bulk Density | 700 g/L |
| Compatible Solvents | MeOH, DCM, MeCN, EtOAc, DMF, DMSO, no major incompatibilities |
| Polymer Type | silica |
| Usage | 2-4 equiv wrt metal or typically screening conditions @ 10wt% wrt API |
» APPLICATION NOTES
Metal Scavengers Metal Mitigation Extractables and Regulatory Perspectives
This study was conducted in 3 parts.
Metal scavengers were investigated for inherent metals content by ICP analysis methods.
Additionally these scavengers were extracted in a range of common solvents in order to show extractable/leachable levels.
We demonstrate an example metal scavenging mitigation step, looking at the corresponding API mass yield, purity and also metals data.
Tags: Application Notes
» BROCHURES
Industrial Product Portfolio
Our carefully selected portfolio of industrial scale products have a proven track record of successful applications and use in scale-up projects. We can support the discovery, development and manufacturing of customer pharmaceutical and biotechnology products, from pre-clinical, phase I, II and III to small scale commercial operations.
Tags: Brochures,
English
» MANUALS & USER GUIDES
Metal Scavenger User Guide
Biotage are leaders in metal scavenging in a variety of different
application areas.
Tags: Manuals & User Guides
» POSTERS
New Applications of Ruthenium Scavenging
Utilization of synthetic chemistry routes developed in late lead
optimization is becoming more widespread as the desire to
efficiently confirm pre-clinical compounds has increased. In some
cases, chemical processes use reagents which are specific and
cannot be substituted on scale up. Such reagents include transition
metal catalysts.
Tags: English,
Posters
Metal Scavengers in Process Chemistry An Investigative Study
Biotage metal scavengers are a more effective alternative to traditional carbon batch adsorption processes. They have the lowest metals content, and also excellent extractable profiles, therefore not likely to risk contamination, unlike competitive materials we tested. Furthermore, Biotage metal scavengers offer volumetrically, a much more compact solution than carbon, requiring 48 times less volume for the same degree of Pd removal in our studies.
Tags: Posters
» PRODUCT NOTES
ISOLUTE® SI Propysulfonic Acid SCX-2 Metal Scavenger
ISOLUTE® Si-Propylsulfonic acid (SCX-2) belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also
Pd, Rh, and Ru.
Tags: Product Notes
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INSTRUCTION VIDEOS
Biotage Metal Scavengers
CONSUMABLES
| Part No. | Description | Product type | Pack Size | Price | ||
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9536-0010 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 10 g | Consumables | 1 | Log in for price | |
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9536-0025 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 25 g | Consumables | 1 | Log in for price | |
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9536-0100 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 100 g | Consumables | 1 | Log in for price | |
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9536-0500 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 500 g | Consumables | 1 | Log in for price | |
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9536-1000 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 1 kg | Consumables | 1 | Log in for price | |
Committed to preserving our shared environment – further details available on request.
Can be used in processes in compliance with cGMP standards.
Manufacture of consumables is accredited by the world renowned British Standards Institute.
Flexible supply chains, back up manufacturing and warehousing ensures supply risk reduction
Can be used in processes in compliance with GLP standards.
Products which are scaleable from lab or development to process scale.
Long to indefinite product shelf life, reduced process risk.
Supports pharma guidelines for reducing elemental impurities in APIs.
Further extractable information provided on request.
Raw materials certified free of materials of human or animal origin.
Chemical substances used in our manufacturing process do not require registration.
Able to withstand mechanical stirring and heating under normal reaction conditions.
Download the product note.
SCX-2 for metal scavenging and purification
ISOLUTE® Si-Propylsulfonic acid (SCX-2) belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also Pd, Rh, and Ru. SCX-2 is typically used as a metal scavenger when the target product is not basic, to avoid the obvious acid/ base product binding interactions with the scavenger. If the product is basic then Si-Tiol, SI TMT, MP-TMT or Si-Trisamine may be utilized instead. Other uses in chemistry include (a) scavenge (removing) amines and other bases from solution (b) as an acid catalyst in reactions or (c) catch and release purification of amines, to facilitate either solvent switching or amine purification. The advantage of using SCX-2 as a polymer supported acid is that it eliminates traditional laborious work-up steps.