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ISOLUTE® Si-Trisamine
Powerful Metal Scavenger with Affinity for Basic Moieties
ISOLUTE® Si-Trisamine is a silica bound propyl-tris(2-aminoethyl)-amine. Si-Trisamine is a very powerful scavenger of electrophiles from aqueous or organic solutions as well as an effective scavenger for transition metals (+II oxidation states).
| Shelf Life | 12 months+ |
| Capacity | 1.6 mmol/g |
| BSE/TSE Statement | yes |
| Scalable | yes |
| Particle Size | 60 microns |
| Bulk Density | 700 g/L |
| Compatible Solvents | Water, ACN, MeOH, DMSO, DCM, THF, DMF, Dioxane |
| Polymer Type | silica |
| Usage | 3 equiv. wrt metal for 30 mins |
» APPLICATION NOTES
Metal Scavengers Metal Mitigation Extractables and Regulatory Perspectives
This study was conducted in 3 parts.
Metal scavengers were investigated for inherent metals content by ICP analysis methods.
Additionally these scavengers were extracted in a range of common solvents in order to show extractable/leachable levels.
We demonstrate an example metal scavenging mitigation step, looking at the corresponding API mass yield, purity and also metals data.
Tags: Application Notes
» BROCHURES
Industrial Product Portfolio
Our carefully selected portfolio of industrial scale products have a proven track record of successful applications and use in scale-up projects. We can support the discovery, development and manufacturing of customer pharmaceutical and biotechnology products, from pre-clinical, phase I, II and III to small scale commercial operations.
Tags: Brochures,
English
» MANUALS & USER GUIDES
Metal Scavenger User Guide
Biotage are leaders in metal scavenging in a variety of different
application areas.
Tags: Manuals & User Guides
» MATERIAL SAFETY DATA SHEETS
Safety Data Sheet BPM 495 SDS 1.1 SI Trisamine
Laboratory Chemical
Not for Therapeutic or diagnostic use
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Material Safety Data Sheets
Safety Data Sheet ISOLUTE SI Triamine
ISOLUTE Si – Triamine
9491
Laboratory chemical
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Material Safety Data Sheets
» POSTERS
New Applications of Ruthenium Scavenging
Utilization of synthetic chemistry routes developed in late lead
optimization is becoming more widespread as the desire to
efficiently confirm pre-clinical compounds has increased. In some
cases, chemical processes use reagents which are specific and
cannot be substituted on scale up. Such reagents include transition
metal catalysts.
Tags: English,
Posters
Metal Scavengers in Process Chemistry An Investigative Study
Biotage metal scavengers are a more effective alternative to traditional carbon batch adsorption processes. They have the lowest metals content, and also excellent extractable profiles, therefore not likely to risk contamination, unlike competitive materials we tested. Furthermore, Biotage metal scavengers offer volumetrically, a much more compact solution than carbon, requiring 48 times less volume for the same degree of Pd removal in our studies.
Tags: Posters
» PRODUCT NOTES
ISOLUTE® Si Trisamine Metal Scavenger
ISOLUTE® Si-Trisamine is a silica bound equivalent of a trisamine base and can scavenge a variety of electrophiles, including aldehydes, acid chlorides, sulfonyl chlorides, isocyanates, isothiocyanates and heavy metal ions such as Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Pb+2, Ru+2 and Zn2+.
Tags: English,
Product Notes
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INSTRUCTION VIDEOS
Biotage Metal Scavengers
CONSUMABLES
| Part No. | Description | Product type | Pack Size | Price | ||
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9495-0010 | ISOLUTE® Si-Trisamine, 10 g | Consumables | 1 | Log in for price | |
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9495-0025 | ISOLUTE® Si-Trisamine, 25 g | Consumables | 1 | Log in for price | |
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9495-0100 | ISOLUTE® Si-Trisamine, 100 g | Consumables | 1 | Log in for price | |
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9495-0500 | ISOLUTE® Si-Trisamine, 500 g | Consumables | 1 | Log in for price | |
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9495-1000 | ISOLUTE® Si-Trisamine, 1 kg | Consumables | 1 | Log in for price | |
Committed to preserving our shared environment – further details available on request.
Can be used in processes in compliance with cGMP standards.
Manufacture of consumables is accredited by the world renowned British Standards Institute.
Flexible supply chains, back up manufacturing and warehousing ensures supply risk reduction
Can be used in processes in compliance with GLP standards.
Products which are scaleable from lab or development to process scale.
Long to indefinite product shelf life, reduced process risk.
Supports pharma guidelines for reducing elemental impurities in APIs.
Further extractable information provided on request.
Raw materials certified free of materials of human or animal origin.
Chemical substances used in our manufacturing process do not require registration.
Able to withstand mechanical stirring and heating under normal reaction conditions.
Download the product note.
Purification and Metal Scavenging
ISOLUTE® Si-Trisamine is a silica bound equivalent of a Trisamine base and can scavenge a variety of electrophiles, including aldehydes, acid chlorides, sulfonyl chlorides, isocyanates, isothiocyanates and heavy metal ions such as Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Pb+2, Ru+2 and Zn2+. Si-Trisamine has a number of uses, it is a very powerful scavenger of transition metals and can also be used as a work-up tool to remove electrophiles or acids in either batch or flow-mode (cartridge) following traditional reflux heated or microwave synthesized reactions.
Metal Scavenging
Heavy metals such as palladium, copper and tin are widely used in diverse transformations and their removal following organic synthesis has become a vital part of the API scale-up process. Si-Trisamine was applied successfully in the scavenging of palladium acetate, copper sulfate and nickel acetate from aqueous and organic solutions.
Scavenging of a 50 mg/50 mL THF/DMA solution of Pd(OAc)2 using a 500 mg/3 mL Si-Trisamine cartridge. Total residence time was 30 seconds, and the solution was allowed to flow through under gravity.
Scavenging of a 250 mg/5 mL aqueous solution of Ni(OAc)2.
Scavenging of a 500 mg aqueous solution of CuSO4.