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- Automated Sample Preparation Instruments
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- ISOLUTE® FILTER+ High Performance Filtration Plates
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-
- ISOLUTE® 101
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- Flash 75/150/400 Cartridges
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- Flash 75/150/400 Systems
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- Discontinued Products
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- Biotage® Horizon SmartPrep
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- KILOPREP Systems and Consumables
- RapidTrace®+
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KILOPREP Systems and Consumables
Discontinued
This product was withdrawn on 31 November 2015.
Biotage® Flash 75/150
Purify up to 400 grams of compound at 1L/min up to 75% faster than with traditional glass columns. Biotage® Flash 75/150 is a simple and reliable system that contains everything you need for separation scale up.
Biotage® Flash 400 System
The Biotage® Flash 400 system is a complete skid-mounted system designed for kilogram scale separations. Built to last and engineered to perform, with materials that comply with FDA regulations and cGMP standards, Flash 400 is the first choice of pharmaceutical and contract manufacturing companies around the world for critical purification applications.
In 1984 ‘KiloPrep’ was filed as a trademark in US and until end 2009, Biotage offered high performance liquid chromatography capabilities with the family of 5 systems (KP100, KP250, KP500, KP2000, KP3000). Even though the instrumentation was discontinued, we continued to offer comprehensive consumables and engineering support many years after, to support our customers. Unfortunately due to recent difficulty in sourcing parts from our suppliers, Biotage has decided to withdraw support for this line of products.
Alternative Products
Whilst there is no direct equivalent high pressure alternative for the KP HPLC systems, Biotage has developed the Flash 75, Flash 150 and Flash 400 purification platforms. A number of our clients have already transitioned to these systems. These robust systems are designed for production, are compliant with cGMP standards and combine the latest developments from stationary phase development, offering unsurpassed purification and process economics. They bridge the performance gap between traditional flash purification techniques and HPLC at a fraction of the price and with much lower operating pressures.
Product Transition Table
|
Original System |
Size (mm) |
Original Flow Rate (mL/min) |
Alternative Cartridge (mm) |
Flow Rate (mL/min) |
Alternative Cartridge / System |
|
KPCM100 |
75x150 |
125-500 |
75x150 |
0-250 |
Flash 75M |
|
|
75x300 |
125-500 |
75x300 |
0-250 |
Flash 75L |
|
KPCM250 |
100x300 |
250-1000 |
150x300 |
0-1000 |
Flash 150M |
|
|
100x600 |
250-1000 |
150x600 |
0-1000 |
Flash 150L |
|
KPCM500 |
150x300 |
500-2000 |
150x300 |
0-1000 |
Flash 150M |
|
|
150x600 |
500-2000 |
150x600 |
0-1000 |
Flash 150L |
|
KPCM1000 |
200x300 |
1000-4000 |
400x300 |
0-6000 |
Flash 400M |
|
|
200x600 |
1000-4000 |
400x600 |
0-6000 |
Flash 400L |
|
KPCM3000 |
300x300 |
2000-8000 |
400x300 |
0-6000 |
Flash 400M |
|
|
300x600 |
2000-8000 |
400x600 |
0-6000 |
Flash 400L |
Advantages of Flash 75/150/400 systems over KiloPrep Systems
- Significantly lower capital costs
- Significantly lower running costs
- Internal bladder not necessary
- All pneumatic, spark free operation
- Easier workflow
- Fully supported
- Incorporates the latest development in stationary phase packing
- Cartridges offer higher loading and consume less solvent
Cartridges that were designed to fit the KiloPrep systems are not compatible with Flash 75/150 or Flash 400 systems, however, many of the cartridges size options and stationary phases are the same. For further information related to method development and transitioning from KilopPrep to the Flash 75/150 or Flash 400 platforms, please contact your local Biotage representative.