Biotage® PS-PPh3-Pd resin is a polystyrene-supported equivalent of the small molecule catalyst tetrakis(triphenylphosphine) palladium(0) [Pd(Ph3P)4]. The primary application for the resin is as a catalyst for Suzuki-Miyaura coupling reactions between arylboronic acids and aryl halides. PS-PPh3-Pd may also have applications in other types of palladium-catalyzed processes in which Pd(Ph3P)4 is used. The Suzuki reaction is one of the most widely practiced coupling protocols for the preparation of symmetrical and unsymmetrical biaryl compounds. The resin was developed to perform in a manner similar to that of the well-established catalyst, while facilitating reagent handling and simplifying workup, product isolation, and removal of palladium.
Powerful Non-nucleophilic Guanidine Base for Alkyation and C-C Bond Formation
Biotage® PS-TBD is a polymer-supported bicyclic guanidine moiety (1,5,7-triazabicyclo[4.4.0]dec-5-ene) base. PS-TBD applications include alkylation of phenols and amines; esterification of carboxylic acids using alkyl halides; alkylation of activated methylene compounds; de-halogenation of organic halides; high throughput synthesis of aryl triflates and aryl nonaflates, and the regioselective synthesis of lysophospholipids.
Self-Indicating TEMPO Oxidation, Reusable and No Work-up Required
Biotage® PS-TEMPO is a novel polymer bound oxidant, based on a polystyrene bound, sulfonic ester linked 2,2,6,6-tetramethylpiperidine-1-oxyl species (PS-TEMPO),. It allows rapid and efficient access to often unstable ketone or aldehyde reactive species, and displays a visual indication of its oxidation state. The color change observed as the oxidation state of the reagent changes, can give an indication of the extent to which the reagent has been used. PS-TEMPO can be regenerated and reused for multiple oxidation reactions.
Easy to Remove Phosphine Oxide for Mitsunobu/Wittig Reaction
Biotage® PS-Triphenylphosphine is a powerful supported phosphine reagent for popular reactions such as Wittig, Mitsunobu, chlorination of acids and alcohols and the scavenging of alkyl halides. Unlike the small molecule reagent, the triphenylphosphine oxide by-product of reaction stays 100% resin bound, meaning that removal of product from phosphine oxide can be accomplished by simple low tech filtration techniques.
Automation for Microwave Assisted Organic Synthesis
Biotage® Initiator+ can be upgraded from a single-sample manual format to an automated 8- or 60-position system. The modular design allows a user to add on different automated sample processors dependent on throughput requirements.
Biotage® SNAP Bio flash cartridges were developed with a small particle size (20 μm) and large pore size (300 Å) to provide increased resolution and the effective separation of complex peptide mixtures.
Reversed-phase flash chromatography is a very effective purification technique. Its main application areas include polar, ionizable and highly lipophilic compounds which cannot easily be separated by normal-phase techniques.
Biotage® KP-NH chemistry shields synthetic organic amines from acidic silanols providing improved selectivity, peak shape, purity and yield. Unlike traditional silica and 1° amine (propyl amine) bonded silica, Biotage KP-NH doesn’t require the use of chlorinated solvents or amine additives.
Biotage SNAP Ultra flash chromatography cartridges deliver the highest purification performance available. Packed with Biotage® HP-Sphere™ spherical silica, these cartridges have the highest loading capacity, lowest backpressure and can withstand high flow rates.
For the efficient automation of oil and grease extraction, EPA Method 1664, the Biotage® Solvent Recovery OG attaches quickly and easily to the exhaust hose from the SpeedVap® Solvent evaporation system.
Designed for high throughput laboratories, the Biotage® SPE Dry 96 and Biotage® SPE Dry 96 Dual Sample Concentrator Systems provide efficient solvent evaporation in microplate format and are compatible with 24-, 96- and 384-well collection plates. Heated gas flow from above and below the collection plate ensures efficient solvent evaporation.
Biotage® V-10 Touch rapidly dries samples dissolved in both aqueous and organic solvents. It easily evaporates HPLC fractions from purification, high boiling point solvents from synthesis and features a novel dry-down onto silica technique for easier dry load capabilities prior to purification.