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A Dissolved / Particulate Baseline Study of PAH’s (Poly-Aromatic Hydrocarbons) in Particulate Laden Water
Part No: AN003-HOR Issued year: 2009 File size: 0.86mb File type: pdf

This study shows that the SPE-DEX® 4790 Automated Extractor system can process water samples containing suspended particulate matter, up to 1000 mg, for the analysis of PAH’s. As PAH’s are found in both the dissolved and particulate phase of the water sample, it is important to be able to handle “whole” water samples such that the particulate matter in the water sample is retained and extracted with the SPE disk. This filtration method ensures that the PAH’s found in the dissolved phase, and those adsorbed onto the particulate matter are properly extracted.

A Dissolved / Particulate Baseline Study of PAH’s (Poly-Aromatic Hydrocarbons) in Particulate Laden Water

A Dissolved / Particulate Baseline Study of PAH’s (Poly-Aromatic Hydrocarbons) in Particulate Laden Water

Part No: AN003-HOR Issued year: 2009 File size: 0.86mb File type: pdf
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A high throughput solid phase extraction method for vitamin B7 (biotin) from pooled human serum prior to mixed mode LC-MS/MS
Part No: TI749E Issued year: 2014 File size: 0.09mb File type: pdf

This application note, developed in conjunction with IMTAKT, describes the extraction of Vitamin B7 (Biotin) from serum using EVOLUTE AX SPE columns.

A high throughput solid phase extraction method for vitamin B7 (biotin) from pooled human serum prior to mixed mode LC-MS/MS

A high throughput solid phase extraction method for vitamin B7 (biotin) from pooled human serum prior to mixed mode LC-MS/MS

Part No: TI749E Issued year: 2014 File size: 0.09mb File type: pdf
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A High-Throughput SPE Method for Extraction of Vitamin B3 (Niacin) and Related Metabolites from Serum Using ISOLUTE® SCX-3 Prior to LC-MS/MS
Part No: AN814 Issued year: 2014 File size: 1.19mb File type: pdf

This application note describes the extraction of Vitamin B3 (Niacin, nicotinic acid) and its key metabolites from serum using a strong cation exchange SPE retention mechanism. High reproducible analyte recoveries are achieved.

A High-Throughput SPE Method for Extraction of Vitamin B3 (Niacin) and Related Metabolites from Serum Using ISOLUTE® SCX-3 Prior to LC-MS/MS

A High-Throughput SPE Method for Extraction of Vitamin B3 (Niacin) and Related Metabolites from Serum Using ISOLUTE® SCX-3 Prior to LC-MS/MS

Part No: AN814 Issued year: 2014 File size: 1.19mb File type: pdf
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A High-Throughput SPE Method to Support the Biomonitoring of Phthalate Metabolites in Human Urine Using ISOLUTE® ENV+ Columns Prior to LC-MS/MS
Part No: AN826 Issued year: 2014 File size: 1.67mb File type: pdf

This application note describes the extraction of nine phthalate metabolites from human urine using ISOLUTE® ENV+ solid phase extraction columns.

A High-Throughput SPE Method to Support the Biomonitoring of Phthalate Metabolites in Human Urine Using ISOLUTE® ENV+ Columns Prior to LC-MS/MS

A High-Throughput SPE Method to Support the Biomonitoring of Phthalate Metabolites in Human Urine Using ISOLUTE® ENV+ Columns Prior to LC-MS/MS

Part No: AN826 Issued year: 2014 File size: 1.67mb File type: pdf
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A New Approach to the Synthesis of Atenolol using Coherent Synthesis™
Part No: 353276 Issued year: 2004 File size: 0.03mb File type: pdf

This report describes the efficient two-step synthesis of Atenolol from p-hydroxyphenylacetamide, using microwave dielectric heating. In both steps, significant acceleration of reaction rates and a slight increase in the yield were achieved compared to conventional procedures.

A New Approach to the Synthesis of Atenolol using Coherent Synthesis™

A New Approach to the Synthesis of Atenolol using Coherent Synthesis™

Part No: 353276 Issued year: 2004 File size: 0.03mb File type: pdf
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A New Strategy to Isolate Combinatorial Arrays
Part No: AN011 Issued year: 1999 File size: 3.64mb File type: pdf

Combinatorial chemistry has become the focus of intense interest as a tool of drug discovery.

A New Strategy to Isolate Combinatorial Arrays

A New Strategy to Isolate Combinatorial Arrays

Part No: AN011 Issued year: 1999 File size: 3.64mb File type: pdf
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A No-Drydown SPE Method for Biomarkers of Alcohol Consumption in Human Urine Using ISOLUTE® NH2 SPE Columns Prior to LC-MS/MS
Part No: AN818.v1 Issued year: 2014 File size: 1.54mb File type: pdf

This application note describes the extraction of ethyl glucuronide and ethyl sulfate from human urine using ISOLUTE® NH2 solid phase extraction columns. The method has been applied real patient samples that had been previously analyzed with a validated referee method. The results of the orthogonal measurements agreed, to provide similar diagnostic values.

A No-Drydown SPE Method for Biomarkers of Alcohol Consumption in Human Urine Using ISOLUTE® NH2 SPE Columns Prior to LC-MS/MS

A No-Drydown SPE Method for Biomarkers of Alcohol Consumption in Human Urine Using ISOLUTE® NH2 SPE Columns Prior to LC-MS/MS

Part No: AN818.v1 Issued year: 2014 File size: 1.54mb File type: pdf
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A Novel Extraction for Synthetic Cannabinoids in Human Whole Blood Using Supported Liquid Extraction Prior to LC-MS/MS Analysis
Part No: AN944 Issued year: 2020 File size: 1.86mb File type: pdf

The development of a novel high-pressure liquid chromatography/ triple quad mass spectrometry method allows for the efficient and accurate identification of 12 synthetic cannabinoids in whole blood by LC-MS/MS. Samples are fortified with internal standard, buffered, and extracted using Supported Liquid Extraction (SLE).

A Novel Extraction for Synthetic Cannabinoids in Human Whole Blood Using Supported Liquid Extraction Prior to LC-MS/MS Analysis

A Novel Extraction for Synthetic Cannabinoids in Human Whole Blood Using Supported Liquid Extraction Prior to LC-MS/MS Analysis

Part No: AN944 Issued year: 2020 File size: 1.86mb File type: pdf
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A Novel Method for Pre-Column Derivatization of Aflatoxin B1, B2, G1, and G2 Prior to HPLC Analysis using the XcelVap® System as a Thermostatically-Controlled Heated Water Chamber
Part No: AN099-HOR Issued year: 2014 File size: 2.06mb File type: pdf

Aflatoxins, a mold largely produced by Aspergillus flavus and Aspergillus parasiticus1 are commonly tested mycotoxins found naturally in a wide range of agriculture crops and food products. Due to their harmful effects on human health, animal health, and global trade, aflatoxins are regulated in most countries and have established global limits in a wide variety of matrices.

A Novel Method for Pre-Column Derivatization of Aflatoxin B1, B2, G1, and G2 Prior to HPLC Analysis using the XcelVap® System as a Thermostatically-Controlled Heated Water Chamber

A Novel Method for Pre-Column Derivatization of Aflatoxin B1, B2, G1, and G2 Prior to HPLC Analysis using the XcelVap® System as a Thermostatically-Controlled Heated Water Chamber

Part No: AN099-HOR Issued year: 2014 File size: 2.06mb File type: pdf
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A Simple Analysis of 4-Methylimidazole using Automated Solid Phase Extraction and High Performance Liquid Chromatography with MS/MS and MS/SIM Detection
Part No: AN111-HOR Issued year: 2016 File size: 2.03mb File type: pdf

The compound 4-methylimidazole (4-MEI) is formed as a byproduct in some foods and beverages. Caramel coloring Type III and Type IV in beverages is one of the ingredients which may contain 4-MEI. Products that potentially contain 4-MEI include certain colas, beers, soy sauces, breads, coffee, ammoniated livestock feed and other products.

A Simple Analysis of 4-Methylimidazole using Automated Solid Phase Extraction and High Performance Liquid Chromatography with MS/MS and MS/SIM Detection

A Simple Analysis of 4-Methylimidazole using Automated Solid Phase Extraction and High Performance Liquid Chromatography with MS/MS and MS/SIM Detection

Part No: AN111-HOR Issued year: 2016 File size: 2.03mb File type: pdf
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A Study of DryDisk® Background Contamination
Part No: AN051-HOR Issued year: 2009 File size: 0.65mb File type: pdf

The DryDisk® Separation Membrane was designed to replace conventional sodium sulfate in the drying of sample extracts. The DryDisk® is a hydrophobic membrane, consisting of a GORETEX ® process filtration media based on polytetrafluroethylene (PTFE). The hydrophobic property of the membrane allows the extracting solvent to pass through it, while retaining any water in the sample extract on the membrane’s surface.

A Study of DryDisk® Background Contamination

A Study of DryDisk® Background Contamination

Part No: AN051-HOR Issued year: 2009 File size: 0.65mb File type: pdf
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A Unique and Simple Matrix Preparation Roadmap for Aflatoxin B1, B2, G1, G2 Food Safety Testing Prior to Automated SmartPrep® Extractor Solid Phase Extraction
Part No: AN098-HOR Issued year: 2014 File size: 2.32mb File type: pdf

Mycotoxin testing awareness has increased as countries involved in world trade of raw agriculture and processed consumer products rely on a safe global food supply. Several mycotoxins are naturally produced and monitored; however, aflatoxins, produced mainly by the Aspergillus species, are considered to be the most important mycotoxin group in the world’s food supply to monitor.

A Unique and Simple Matrix Preparation Roadmap for Aflatoxin B1, B2, G1, G2 Food Safety Testing Prior to Automated SmartPrep® Extractor Solid Phase Extraction

A Unique and Simple Matrix Preparation Roadmap for Aflatoxin B1, B2, G1, G2 Food Safety Testing Prior to Automated SmartPrep® Extractor Solid Phase Extraction

Part No: AN098-HOR Issued year: 2014 File size: 2.32mb File type: pdf
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Acidic, Basic, and Neutral Drug Screen of Hydrolyzed Urine Using Supported Liquid Extraction Prior to LC-MS/MS Analysis
Part No: AN859 Issued year: 2016 File size: 0.93mb File type: pdf

This application note describes the extraction of acidic, basic, and neutral drugs from urine for screening purposes using ISOLUTE® SLE+ supported liquid extraction plates prior to LC-MS/MS analysis.

Acidic, Basic, and Neutral Drug Screen of Hydrolyzed Urine Using Supported Liquid Extraction Prior to LC-MS/MS Analysis

Acidic, Basic, and Neutral Drug Screen of Hydrolyzed Urine Using Supported Liquid Extraction Prior to LC-MS/MS Analysis

Part No: AN859 Issued year: 2016 File size: 0.93mb File type: pdf
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Activated Carbon De-Colorization using Prepacked Disposable Cartridges
Part No: AN002 Issued year: 2000 File size: 0.81mb File type: pdf

The removal of colored impurities (De-colorization) from natural products, organic and inorganic compounds at bench scale and industrial scale in commonly accomplished via batch charcoal absorption techniques.

Activated Carbon De-Colorization using Prepacked Disposable Cartridges

Activated Carbon De-Colorization using Prepacked Disposable Cartridges

Part No: AN002 Issued year: 2000 File size: 0.81mb File type: pdf
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All-Wavelength Collection on the CombiFlash Rf and CombiFlash Torrent Systems
Part No: AN81 Issued year: 2010 File size: 0.55mb File type: pdf

Teledyne Isco App Note, All Wavelength Detection Isco only provides the trace for all wavelength detection, there is no purity check and no way to display the entire UV spectrum during a run.

All-Wavelength Collection on the CombiFlash Rf and CombiFlash Torrent Systems

All-Wavelength Collection on the CombiFlash Rf and CombiFlash Torrent Systems

Part No: AN81 Issued year: 2010 File size: 0.55mb File type: pdf
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An Improved Solvent Drying Technique for Enhanced Recovery of Organic Compounds
Part No: AN052-HOR Issued year: 2009 File size: 0.72mb File type: pdf

Effective removal of residual water from organic solvents is critical to achieve optimal recoveries for water soluble compounds. Sodium sulfate has been the standard technique for removing residual water from solvent extracts for many years; however, it has several major drawbacks. Water soluble analytes in the residual water phase can become adsorbed in the sodium sulfate, leading to lower recoveries.

An Improved Solvent Drying Technique for Enhanced Recovery of Organic Compounds

An Improved Solvent Drying Technique for Enhanced Recovery of Organic Compounds

Part No: AN052-HOR Issued year: 2009 File size: 0.72mb File type: pdf
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An In-Well Hydrolysis Solid Phase Extraction Method Using EVOLUTE® HYDRO CX for 96 Licit and Illicit Drugs of Abuse from Urine Prior to UPLC-MS/MS
Part No: AN886 Issued year: 2017 File size: 1mb File type: pdf

This application note describes the extraction of 96 licit and illicit drugs of abuse from urine prior to UPLC-MS/MS analysis using EVOLUTE® HYDRO CX 96-well plates. EVOLUTE® HYDRO CX plates offer an efficient way to perform hydrolysis in the well of the extraction plate. This method provides high analyte recovery, reduced extraction time due to the elimination of a sample transfer step as well as the elimination of the column conditioning and equilibration steps, and a reduced risk for sample carryover or cross-contamination due to the elimination of the sample transfer step.

An In-Well Hydrolysis Solid Phase Extraction Method Using EVOLUTE® HYDRO CX for 96 Licit and Illicit Drugs of Abuse from Urine Prior to UPLC-MS/MS

An In-Well Hydrolysis Solid Phase Extraction Method Using EVOLUTE® HYDRO CX for 96 Licit and Illicit Drugs of Abuse from Urine Prior to UPLC-MS/MS

Part No: AN886 Issued year: 2017 File size: 1mb File type: pdf
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AN938 Determination of Pesticide Recovery Rates from Fruit and Vegetables Using QuEChERS and Biotage Lysera
Part No: AN938 Issued year: 2020 File size: 1.01mb File type: pdf

This application note evaluates the effectiveness of bead mill homogenization on the Biotage® Lysera for multiple pesticide extraction using the QuEChERS AOAC 2007.01 method.

AN938 Determination of Pesticide Recovery Rates from Fruit and Vegetables Using QuEChERS and Biotage Lysera

AN938 Determination of Pesticide Recovery Rates from Fruit and Vegetables Using QuEChERS and Biotage Lysera

Part No: AN938 Issued year: 2020 File size: 1.01mb File type: pdf
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Analysis and Purification of Combinatorial Arrays
Part No: AN017 Issued year: 1999 File size: 1.32mb File type: pdf

A crucial aspect of combinatorial solution phase chemistry strategy is monitoring the reaction progress to assure its completion and to quickly separate and identify the compounds produced.

Analysis and Purification of Combinatorial Arrays

Analysis and Purification of Combinatorial Arrays

Part No: AN017 Issued year: 1999 File size: 1.32mb File type: pdf
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Analysis of Acid Herbicides in Drinking and Surface Water Using On-line SPE-LC-MS/MS
Part No: AN863 Issued year: 2016 File size: 1.62mb File type: pdf

This application note describes the use of ISOLUTE® ENV+ on-line cartridges in a fully automated on-line SPE-LC-MS/MS method for extraction and quantification of 16 acid herbicides in drinking and surface water.

Analysis of Acid Herbicides in Drinking and Surface Water Using On-line SPE-LC-MS/MS

Analysis of Acid Herbicides in Drinking and Surface Water Using On-line SPE-LC-MS/MS

Part No: AN863 Issued year: 2016 File size: 1.62mb File type: pdf
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