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Biotage® Dalton 2000 Mass Detector

Bringing Mass Detection to Flash Chromatography

dalton 2000 highlight DALT-2000-APCI-230V

"Simultaneous detection of both positive and negative ions is fantastic.  Rarely do samples contain just positively or negatively charged species."

Biotage® Dalton 2000 is a compact single quadrupole mass detector with simultaneous positive and negative polarity switching. Biotage® Dalton 2000 uses an atmospheric pressure chemical ionization source to ionize substances, which can then be identified by their mass-to-charge ratios (m/z). Biotage® Dalton 2000 allows you to analyze samples and automatically use the m/z ratio(s) of the identified substance(s) for flash purification.

A novel function, 'Collect on TIC', monitors the entire specified range of m/z values. This is beneficial for samples that easily form fragments and/or adducts, where peaks are therefore found on several m/z values, or if the sample contains many different components.

Tailored Technology

Dalton 2000 can be used with Isolera One flash purification instrument to automate the compound identification and purification. 

The minimal user intervention required makes it ideal also for chemists unfamiliar with mass detection or those whose priorities lie in compound synthesis rather than analysis.

Intelligent Integration

The seamless interaction between the flash system and the mass detector is managed by the Isolera™ Dalton Nanolink interface, an intelligent sampling device that provides Biotage® Dalton 2000 Mass Detector with the exact amount of sample required, and dynamically adjusts to the solvent effluent flow rate employed in the Flash system.

Isolera™ Spektra software with its graphic user interface provides a straightforward controlling environment, giving easy access to the process.

Flash Purification of Peptides

Combining Isolera™ purification system with Dalton 2000 will allow to experience true mass-directed flash chromatography of peptides. Mass-based fractionation offers the advantage of being able to separate products with no UV signal and also resolve peaks with overlapping UV signals such as peptidic deletion sequences. 


  • Compound identification by mass during purification and by direct injection analysis
  • Fully automated integration of Flash purification and mass detection via the Isolera™ Dalton Nanolink
  • Automatically accommodates different flash flow rates
  • Simple wizard-based approach to method development