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Biotage® Flash 75 System

Purify up to 100 g at 250 mL/min

Scale-up purification separation Flash 75 large columns

Biotage® Flash 75 is a simple, robust and reliable system that contains everything needed for separation and scale-up. Operating at a flow rate of 250 mL/ min, supporting separations of up to 100 g per run, these flash systems and cartridges allow you to quickly develop scale-up and complete runs, saving hours – even days – of purification time. A variety of pre-packed cartridges are available depending on the purification goal and cartridges can also be custom packed with your preferred chromatography stationary phase.

Reliable Scale-up – Faster

Biotage® Flash 75 systems safely operate at 100 psi enabling fast flow rates and the use of high viscosity solvents. Our proven, patented radial compression technology ensures near zero “wall effects” and channelling inside each column. This maintains the bed’s stability, rendering cleaner, purer fractions in less time and higher overall product yield. Routinely operating at a flow rate of up to 250 mL/min, these purification systems allow you to quickly scale-up and complete runs, saving hours or even days of purification time.

75% Time Saving

In a comparison between a Biotage Flash 75L cartridge (75 mm x 300 mm) and a 110 mm x 200 mm traditional glass column, fractions were collected in 2.5 hours using the glass column, while the Flash 75L cartridge required just 40 minutes. Additionally there were fewer mixed fractions, resulting in greater product purity.

Complete Kit

The system includes an easy-to-install radial compression module, a fully integrated air manifold, solvent reservoir, a start-up kit with all necessary tubing, grounding kit, and a user’s manual. Flash 75 systems come with a sample injection module (SIM) as standard, which helps to bridge the gap from lab to large scale method development. The SIMs (available in 100 mL, 500 mL, 1000 mL and 2000 mL) facilitates the handling of routine samples as well as viscous oils and samples with poor solubility.

Dependable and Flexible

All Biotage Flash 75 cartridges are constructed of medium-density polyethylene to resist cracking and splitting and meet the FDA extractables requirement specified in 21 CFR 177.1520. There is no breakable glass, and all of the silica is completely self-contained, eliminating any exposure to silica dust or contaminants. A variety of accessories, including sample injection modules, solvent reservoirs, compression module barrels are available to maximum convenience, utility and safety of the system. 

Committed to preserving our shared environment – further details available on request.

Manufacture of consumables is accredited by the world renowned British Standards Institute.

Flexible supply chains, back up manufacturing and warehousing ensures supply risk reduction

Products which are scaleable from lab or development to process scale.

Can be used in processes in compliance with GLP standards.

For more information download the Industrial Product Portfolio Catalog.